Your Knowledge Hub for Alzheimer’s and Cognitive Health

Discover insights, expert explanations, and practical tips to help you navigate memory loss, mild cognitive impairment (MCI), Alzheimer’s, and new therapy options like VGuard.

Blog Articles

Stay informed with regularly updated, science-based articles

The Role of Sleep Stages in Memory Consolidation and How to Improve Them

Why Sleep Is Essential for Memory Sleep is one of the most powerful yet underestimated biological processes supporting brain function. Over [...]

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Cognitive Reserve: What It Is and How It May Slow Memory Decline

Cognitive Reserve: What It Is and How It May Slow Memory Decline What Is Cognitive Reserve? Cognitive reserve describes the brain’s [...]

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10 Early Signs of Alzheimer’s Disease: Key Signs and Symptoms You Shouldn’t Ignore

10 Early Signs of Alzheimer’s Disease: Key Signs and Symptoms You Shouldn’t Ignore There’s a moment — usually small, almost [...]

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Frequently Asked Questions

Answers to the most common questions from patients, caregivers, and clinicians

Vguard is a non-invasive, night-time neurostimulation therapy designed to support memory and cognitive function. It works during sleep by delivering stimulation to the auricular branch of the vagus nerve (aVNS). This activates the hippocampus — the brain’s memory center. It is used at home, without drugs, pain, or invasive procedures.
Early clinical trials show that Vguard is well tolerated, with only mild, infrequent side effects (6% mild skin irritation, 6% mild headaches). The device has received CE medical certification, which confirms that it meets EU medical safety and quality standards. It is designed for regular, nightly use.
MCI is an early form of cognitive decline where memory or thinking skills worsen more than expected for age, but daily independence is still maintained. People with MCI are at increased risk of developing Alzheimer’s disease.Vguard was specifically created for people with MCI and early Alzheimer’s.
Unlike drugs, which often provide short-term symptom relief and may cause side effects, Vguard activates the brain’s natural memory mechanisms during sleep — without pharmacology, injections, or invasive procedures. Key differences: Non-invasive and drug-free, used during sleep, Activates hippocampal activity. Safe with minor side effects.
Theta waves are natural brain rhythms strongly related to memory formation and learning. During sleep, theta waves help the brain organize memories, strengthen neural connections, and consolidate learning.Studies show that Vguard supports the generation of hippocampal theta waves, which is one of the mechanisms behind its cognitive benefits.
Vagus nerve stimulation (VNS) is a neuromodulation technique that delivers mild electrical signals to the vagus nerve — a major communication pathway between the brain and body.Vguard uses auricular VNS (aVNS), a non-invasive form where stimulation is applied to a small area of the ear that connects directly to the brain’s memory circuits.
Yes. Vguard has received CE certification, confirming compliance with EU medical device safety, quality, and performance standards.
Patients will be able to join upcoming clinical studies once the next multicenter trial is launched.To express interest or join the waiting list: 📩 Email: med@cogniguard.com.
Vguard is designed for adults diagnosed with mild cognitive impairment (MCI) or early-stage Alzheimer’s disease. It’s medical device available by physician prescription only. Contact your local clinician or Cogniguard center to identify where you may be qualified for Vguard therapy.
Yes. Vguard is non-pharmacological, which means it does not interact with medications. It can be used as a complementary therapy alongside standard treatments prescribed by neurologists or psychiatrists. Always consult with your healthcare provider before making changes to your therapy plan.
Vguard is designed to work during sleep, synchronized with natural sleep cycles. While it is not a sleep therapy, users report that it works without disturbing sleep, and some experience more refreshing rest because the therapy aligns with natural memory consolidation processes.
No. Vguard delivers very gentle, below sensitivity threshold electrical impulses to the auricular branch of the vagus nerve. Users do not feel pain, and in clinical trials the device was rated as comfortable to wear throughout the night. Side effects were rare and mild (e.g., slight skin irritation).
In clinical trials, improvements in memory and cognitive performance appeared after 12 weeks of regular nightly use. Research suggests that consistent, long-term use may help maintain cognitive function and slow decline.
Vguard stimulates the vagus nerve to activate the hippocampus, which is responsible for memory. During sleep, the device helps generate theta brain waves, which support: - memory consolidation - information processing - neural regeneration
Yes. The device was specifically designed for older adults, including those with age-related memory loss. It is simple to use, safe, and non-invasive. The comfortable ear-mounted design and mobile app make it suitable even for people with limited technological experience
Most neurostimulation devices are: - used in clinics - expensive - invasive (implanted) - or require daytime sessions Vguard is the first non-invasive, home-based vagus nerve stimulation therapy used during sleep, active during memory consolidation phases. Its patented skin–electrode interface and sleep-aligned stimulation protocol make it unique.
Vguard is backed by: - preclinical studies confirming hippocampal activation - fMRI evidence showing increased blood flow in memory areas - clinical trials with significant cognitive improvement (up to +7 points ADAS-Cog) - CE medical certification and 7 patents protecting the technology
Yes. The Vguard mobile app allows caregivers, family, or physicians to: track therapy sessions and monitor adherence.
Nighttime is when the brain naturally performs memory consolidation. Vguard delivery stimulation trough various phases of sleep — also REM and light sleep — when the hippocampus is most receptive to therapeutic activation
Common signs include: - difficulty recalling recent events - losing track of conversations - forgetting appointments - reduced focus or slow processing - repeating questions If you notice these symptoms, consult a neurologist or memory clinic. The Vguard therapy is tailored specifically to this early stage.
Clinical data suggests that improvement in memory, attention, and daily function could help extend independence and reduce caregiver burden. While research is ongoing, early results are promising.

Glossary of Terms

Break down the science with easy-to-understand definitions:

  • Biomarker – A measurable indicator of a biological condition or process, often used in diagnosis.
  • Amyloid Plaques – Protein deposits found in the brains of Alzheimer’s patients.
  • Tau Protein – A protein involved in stabilizing neurons, often misfolded in Alzheimer’s.
  • EEG (Electroencephalogram) – A test that records brain wave activity.
  • Functional MRI (fMRI) – Imaging that shows brain activity by detecting blood flow changes.
  • Stimulation Protocol – A set of parameters for applying therapeutic stimulation.
  • Electrode – A conductive device that delivers electrical impulses in neurostimulation.
  • Neurocircuitry – Networks of neurons responsible for specific brain functions.
  • Sleep Architecture – The structure and pattern of different sleep phases during a night.
  • REM Rebound – An increase in REM sleep after periods of sleep deprivation.
  • Synaptic Plasticity – The ability of synapses to strengthen or weaken over time
  • Cognition – Mental processes such as memory, attention, and problem-solving.
  • Executive Function – High-level cognitive skills like planning, decision-making, and multitasking.
  • Neurotech – Technology developed to understand or influence brain function.
  • Precision Medicine – Customized healthcare based on individual characteristics.
  • Cognitive Reserve – The brain’s resilience to damage through flexible cognitive strategies.
  • Functional Connectivity – Coordination of activity across different brain regions.
  • Actigraphy – A method of monitoring rest/activity cycles using wearable sensors.
  • Patient Adherence – The extent to which a patient correctly follows medical advice.
  • Safety Profile – A summary of known risks and side effects of a medical intervention.
  • Alzheimer’s Disease (AD) – A progressive neurodegenerative disease affecting memory and thinking.
  • Dementia – A general term for cognitive decline affecting daily functioning.
  • Neurodegeneration – Gradual loss of neuron structure or function, often leading to dementia.
  • Non-Invasive Therapy – A treatment that doesn’t require surgery or skin penetration.
  • Clinical Trial – A research study to test medical, surgical, or behavioral interventions in humans.
  • Double-Blind Study – A clinical study where neither participants nor researchers know who receives the actual treatment.
  • Placebo-Controlled Trial – A trial that compares a treatment to an inactive substance.
  • Electrode-Skin Interface – The contact point in a medical device where stimulation is applied.
  • Neuroplasticity – The brain’s ability to reorganize and form new neural connections.
  • Cognitive Decline – A deterioration in cognitive function such as memory and reasoning.
  • Neurostimulation – The use of targeted electrical pulses to modulate nervous system activity.
  • Auricular VNS – Vagus nerve stimulation delivered through the outer ear.
  • Digital Health Platform – A technology-based system for remote patient care and monitoring.
  • Breakthrough Device (FDA) – A designation for innovative devices offering substantial benefits.
  • Pilot Study – A small-scale preliminary study to test feasibility, time, and cost.
  • Pivotal Study – A confirmatory trial used to support regulatory approval.
  • Hippocampal Theta Activation – A type of brain wave activity linked to memory, induced via stimulation.
  • Memory Consolidation – The neurological process of converting short-term memories into long-term storage.