Confidence through ongoing

Preclinical & Clinical Research

Where Neuroscience, and Engineering converge to improve cognitive skills

At Cogniguard we are committed to delivering science-based  therapy for MCI and early Alzheimer’s patients. Our team of neuroscientists, clinicians and biomedical engineers has spent years developing and refining the Vguard solution.

Vguard delivers special neurostimulation treatment, proven in an animal study model, to generate Theta Waves, which have been shown to reflects Hippocampal activity.

This innovative approach enhances cognitive function, preserves memory, and slows the progression of cognitive decline.

 

Pre-clinical Validation

  • 5+ Years of Animal Trials
    First in neuroscience revolutionary discovery of unique stimulation protocol capable of hipocampal Theta  Wave generation during Vguard stimulation.
  • Preparation of proprietary stimulation protocol designed for nocturnal stimulation and enhancement of cerebral memory centers activity
  • Application of night stimulation as support to vagal activity at nigh lowered in elderly persons
  • Scientifically validated by Peer-Reviewed Research 7 publications in leading neuroscience journals.

Clinical research:

First  proof of concept clinical test in form of double blinded, randomized  placebo controlled study performed in 2 independent clinical centers in Poland and Tel-Aviv shows statistically significant cognitive improvement ( results assessed by ADAS-Cog, MMSE, Color Trail Test, Verbal Memory Probing).

Mechanism of Action: How Vguard Activates the Brain

  • Vguard uses auricular vagus nerve stimulation (aVNS) to influence the hippocampus, enhancing physiological performance of hippocampus and other brain memory centers.

Hippocampus Activation – Animal model

The company established the therapy  mechanism of action through fundamental research in animal, demonstrating a direct link between electrical stimulation of the vagus nerve and cognitive arousal.

In these studies,  or the first time the presence of hippocampal type II theta in response to the application of VNS  was demonstrated.
This discovery is groundbreaking in showing the impact of VNS stimulation on hippocampal function, a key brain structure responsible for memory processing.
The research enabled the development of a stimulation protocol used in the Vguard method. The results of our studies have been published in a series of research papers in renowned scientific journals.

References:

Brain Research 1675, November 2017, Pages 41-50

Brain Res Bull. 147, Apr 2019, pages 110-123

Brain Res Bull. 152 Oct 2019, pages 236-245

In double-blind, randomized, placebo controlled clinical PoC settings on the group of 60 patients, in 2 independent clinical centers in Poland and Israel, participants showed statistically significant cognitive improvements using following cognitive tests :

  • ADAS-Cog
  • MMSE
  • Verbal Memory Probing
  • Colour Trails Test (CTT)

Study 1: 6+-point ADAS-Cog improvement in treatment group

Study 2:  4+ points ADAS-Cog improvement in treatment group

Why It Matters: From Synapse to Society

By improving cognitive function, Vguard aims to reduce caregiver burden, delay institutionalization, and empower families to preserve the quality of life.

Publications

  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2021, Noradrenergic Profile of Hippocampal Formation Theta Rhythm in Anaesthetized Rats
  • Broncel A. ,Bocian R. , Kłos-Wojtczak P. , Kulbat-Warycha K. , Konopacki J. 2019, Vagal nerve stimulation as a promising tool in the improvement of cognitive T disorders.
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2018. Medial septal cholinergic mediation of hippocampal theta rhythm induced by vagal nerve stimulation. Plos One. 5;13(11).
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2018. Some technical issues of vagal nerve stimulation. An approach using a hippocampal formation theta rhythm. Brain Res Bull. 140:402-410.
  • Broncel A., Bocian R., Kłos-Wojtczak P., Konopacki J. 2017. Vagus nerve stimulation produces a hippocampal formation theta rhythm in anesthetized rats. Brain Res. 1675:41-50.
  • Broncel A, Bocian R, Kłos-Wojtczak P, Kulbat-Warycha K, Konopacki J. Brain Res Bull. 2020 Feb Vagal nerve stimulation as a promising tool in the improvement of cognitive disorders.
  • Broncel A, Bocian R, Kłos-Wojtczak P, Konopacki J. Brain Res Bull. 2019 Oct Hippocampal theta rhythm induced by vagal nerve stimulation: The effect of modulation of electrical coupling.
  • Broncel A, Bocian R, Kłos-Wojtczak P, Konopacki J. Brain Res Bull. 2019 Apr GABAergic mediation of hippocampal theta rhythm induced by stimulation of the vagal nerve.